Expert Opin Drug Saf. Take the anti-diarrhea medicine as directed on the label, or as prescribed by your doctor. Other interactions can increase side effects or make them more severe. All these studies were randomized, double-blind, placebo-controlled trials comparing Ofev 150 mg twice daily to placebo for 52 weeks. An acute exacerbation is a sudden deterioration in respiratory function, in many cases with unknown cause, which negatively impacts the disease course and often leads to death within a few months. It works by blocking the action of enzymes involved in causing fibrosis. You will start taking Nintedanib as one 150mg capsule, twice a day. Ofev is an effective treatment for idiopathic pulmonary fibrosis. Velagacherla V, Suresh A, Mehta CH, Nayak UY, Nayak Y. Visit www.fda.gov/safety/medwatchor call 1-800-FDA-1088. Ofev comes in two strengths: 100 milligrams (mg) and 150 mg. For the types of lung disease Ofev is approved to treat, the usual recommended dosage is 150 mg twice per day. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. 8600 Rockville Pike Dosing & What To Expect - OFEV (nintedanib) Capsules Diarrhea is usually mild or moderate, but in some cases, it can be severe. They will usually contact you within 2 weeks of your appointment at Southmead hospital to arrange dates for delivery. -Conduct a pregnancy test in females of reproductive potential prior to initiating therapy. With autoimmune conditions, your immune system mistakenly attacks your bodys own healthy cells. You should not breastfeed while taking nintedanib. Nintedanib may cause other side effects. Continue reading, There has been one phase 4 trial that has investigated the combination of Ofev (nintedanib) and Esbriet (pirfenidone) for idiopathic pulmonary fibrosis (IPF) that showed a slightly increased risk of side effects with combination treatment, but the trial was not large enough to make a solid conclusion about increased/decreased effectiveness. N Engl J Med 2005; 353: 22292242. If you have a sexual partner whos able to become pregnant, talk with your doctor about your birth control needs while taking Ofev. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
